Cdx2p-creert2
WebMay 1, 2024 · CDX2P-CreERT2 mice express CreERT2 throughout the entire intestinal epithelium under the control of the CDX2 promoter . AhR f/f mice carry loxP sites …
Cdx2p-creert2
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WebMar 12, 2024 · Introduction. Colorectal cancer (CRC) is the third leading cause of cancer-related death in the USA and thought to arise from the acquisition of multiple mutations of genes controlling colon epithelial cell growth and differentiation that have accumulated over several decades ().Among these genes, mutation of the adenomatous polyposis coli … WebColorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colore…
WebKRas mouse model (Fig. 1A), CDX2P-CreERT2 mice (RRID: IMSR_JAX:022390) were crossed with LSL-K-ras G12D mice (RRID:IMSR_JAX:008179). Mice were housed in cages in a temperature- and humidity-controlled animal facility with a 12 h light/dark cycle and fed lab chow. For in vivo diet studies, mice were fed experimental diets WebThe Cux2-CreERT2 "knock-in" allele has the CreER T2 fusion protein (CreERT2 fusion protein) inserted into the first coding ATG of the cut-like homeobox 2 (Cux2) locus; this was designed to both abolish Cux2 gene function (see details below) and place CreER T2 expression under the control of the Cux2 promoter/enhancer elements. Heterozygous …
WebNov 1, 2024 · Recently, colon-specific deletion of Apc has been achieved through the use of the colon-specific Cre construct, CDX2P-CreERT2 [19]. These mice carry a CDX2-NLS … WebFeb 1, 2024 · 99 A mouse model for APC-deficient colonic polyposis, CDX2P-CreERT2 Apcfl/fl, demonstrated that treatment with rapamycin led to better median survival (P=0.003), fewer polyps (P=0.001), and decreased expression of β-catenin and Sox9 compared to the control cohort. 100 Similar to rapamycin, everlimous has mTOR blocking effects by …
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WebOrganoid from colon sample of tamoxifen treated CDX2P-CreERT2, Apc fl/+, Kras LSL-G12D/+, Tpr53 fl/fl mouse 1: Organism: Mus musculus: Characteristics: strain: mixed C57BL/6 and 129 background treatment: 70 mg/kg tamoxifen, on 2 consecutive days Sex: Male: Extracted molecule: total RNA: Extraction protocol bsn bauservice nord gmbhWeb022390 - CDX2P-CreER [T2] Strain Details. Technical Information Scientists. Overview. How it's Used. MGI Workshops. If you would like to host an MGI workshop at your institution, … bsnb careersWebApr 4, 2024 · Mutation details: The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a … exchange online edit retention policyWebColon Adenocarcinoma from tamoxifen treated CDX2P-CreERT2, Apc fl/+, Kras LSL-G12D/+, Tpr53 R270H/fl mouse 7: Organism: Mus musculus: Characteristics: strain: mixed C57BL/6 and 129 background treatment: 70 mg/kg tamoxifen, on 2 consecutive days Sex: Male: Extracted molecule: total RNA: Extraction protocol exchange online edit connectorWebNov 1, 2024 · Inactivation of CDX2 combined with BRAF V600E expression using CDX2P-creERT2, which is expressed in terminal ileum and colon, promotes serrated benign and invasive tumors that are enriched with the EMT gene signature [51]. Balbinot et al. demonstrated that the mosaic KO of CDX2 in the mouse intestinal epithelium using the … bsnb ballston spaWebDownload scientific diagram Inactivation of a Ctnnb1 allele in Apc-mutant mouse colon epithelium reduces aberrant expansion of the presumptive stem cell pool expressing Msi1 or Lgr5. (A) GFP ... exchange online emailWebOur model is also different from the previously generated colon-specific CDX2P–CreERT2 transgene where Cre is expressed in both stem and differentiated epithelial cells of the … exchange online edit global address list