Pttg1 and p53

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August undefined, 2024

WebAug 18, 2024 · It should be noted that the PTTG family interacts with p53. For example, PTTG1 is thought to influence p53 activity by blocking p53 binding to DNA . Moreover, Méndez-Vidal et al. indicated that PTTG2 silencing results in increased levels of p53 protein . Suppressor p53 serves an important role in the cellular homeostasis maintenance . WebMar 12, 2007 · For example, PTTG1 may bind to p53 and inhibit p21 transactivation (Bernal et al., 2002) which facilitates Rb phosphorylation, enabling the G1/S transition. c-Myc, induced by PTTG1, may in turn ...

PTTG1 expression is associated with hyperproliferative …

WebOct 6, 2015 · Notably, some of the genes found to strongly correlate with PTTG1 expression in this study, including CDK1, CCNB1, CCNB2 and BIRC5 are known to be inhibited downstream of p53 [68–70]; p53-mediated regulation of gene expression down stream of PTTG1 could be a focus of future studies. However, we found no correlation between … WebJun 21, 2024 · In addition, the existence of a complex network among p53 family members (p63 and p73) and their interactions with other factors that promote thyroid cancer progression has been well documented. ... The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology 2014, 155, 1222–1234. [Google … diagnostically related groups

Prognostic Significance of PTTG1 and Its Methylation in Lung

WebThe PTTG1-Binding Factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a proto-oncogene. ... Impaired p53 function was evident in a transgenic mouse model with thyroid-specific PBF over-expression (PBF-Tg), which had significantly increased genetic instability as indicated by FISSR-PCR ... WebDec 25, 2024 · Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. ... protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor … WebOct 20, 2008 · They also observed apoptosis by PTTG1 in p53-negative MG-63 cells. The transient or stable expressions of PTTG1 in these cells were found to increase the frequency of aneuploidy. ... Puri R, Tousson A, Chen L, Kakar SS: Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Lett 2001 ... diagnostic algorithm asthma

HBXIP Regulates Gastric Cancer Glucose Metabolism and …

The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in ...

WebAug 17, 2011 · Cell lines and reagents. HCT116 is a human colon carcinoma cell line, expressing wild-type p53 and PTTG1 genes, and HCT116 p53 −/− and HCT116 PTTG1 −/− cell lines were derived using homologous recombination to knock out p53 or PTTG1 respectively , .Cells were cultured in McCoy's 5A medium containing 15% FBS. WebPTTG1 has been shown to interact with: DNAJA1, Ku70; P53, PTTG1IP, and; RPS10. Regulation. During Mitosis CDK1 phosphorylate PTTG1 at Ser-165. PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase … diagnostica memoria windows”WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are … diagnostic algorithm for cushing\u0027s syndrome

"WebApr 20, 2006 · To this end, we examined the effect of PTTG1 depletion on endogenous levels of p53 and p21. p21 is one of many genes to be induced by p53 and functions as a cyclin-dependent kinase inhibitor, which induces in cell-cycle arrest at G1 phase. 34 p53 level was not markedly affected by PTTG1 depletion, but p21 level was increased in a viral … " - Pttg1 and p53

Pttg1 and p53

[Pituitary tumor transforming gene 1 (PTTG1) is highly ... - PubMed

WebFeb 1, 2011 · The expressions of Caspase-3, Bax, p21 and p53 in HepG2 and SMMC-7721 cells were significantly increased after siRNA knockdown of PTTG1 expression. In conclusion, the PTTG1 gene is up-regulated in the cancerous tissue from patients with HCC and involved in the progression of HCC. WebJul 24, 2024 · PTTG1 may also block p53 and regulate DNA repair mechanisms and apoptosis (Hornig et al., 2002). Our group has assessed a cohort of HTLV-1 asymptomatic carriers with the goal of finding clinical and molecular aspects related to ATL progression ( Sanabani et al., 2012 ; Pessoa et al., 2014 ; de Souza et al., 2024 ).

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WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. ... PTTG1 staining was one of the histological features (numerous mitoses, high Ki-67 index, and nuclear labelling of PTTG1 and P53) distinguishing aggressive–invasive PRL tumors from those behaving less aggressively ... WebNov 1, 2009 · PTTG1–p53 interaction was then demonstrated by phage display assay (Bernal et al. 2002). The assay indicated that PTTG1 interacts with a p53 fragment containing residues 109–374. Glutathione S-transferase (GST) pull-down assay indicates that residues (aa 300–374) of p53 and residues (aa 66–99) of PTTG1 are important for …

WebJun 29, 2024 · Background Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is intended to analyze the aberrant expression and clinical significance of PTTG1 in BLCA, explore the relationship between … WebPituitary tumor-transforming gene 1 protein (PTTG1) immunostaining and P53 expression. Source publication Upregulation of PTTG1 is associated with poor prognosis in prostate cancer

WebJul 16, 2010 · To gain insight into the molecular basis of PTTG1-induced growth arrest and senescence in normal fibroblasts, we examined the expression pattern of several key cell cycle regulators that are involved in senescence using immunoblotting analysis.In IMR90 cells, PTTG1 overexpression consistently induced p53 expression and inhibited Rb protein … WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ...

WebJul 28, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) has been identified as an oncogene and is overexpressed in many tumor types. However, the role of PTTG1 in glioblastoma (GBM) has not been well characterized, especially in relation to angiogenesis, migration, and invasion. ... VEGF, MMP2, MMP9, MMP14, p53, p21 and cyclin D1. Pearson …

WebAs PTTG1 (pituitary tumor transforming gene) abundance correlates with adverse outcomes in cancer treatment, we determined mechanisms underlying this observation by assessing the role of PTTG1 in regulating cell response to anti-neoplastic drugs. ... Binding of Sp1, p53 and p300 to the p21 promoter was enhanced in PTTG1(-/-) cells after ... diagnostically synonymWebPTTG1 . directly caused apoptosis in colorectal car - cinoma HCT116 cells. 15. Overexpression of PTTG1 will induce aneuploidy, which in turn causes apopto-sis. 13. Both p53 and PTTG1 are associated with cell cycle regulation, tumor develop-ment, DNA damage repair and apoptosis. Overexpression of PTTG1 inhibits the activation of separase, in ... diagnostic analysis in businessWebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … cinnabar operatingWebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. ... Moreover, the UBE2C-mediated P53 ubiquitination could be a potential target in LIHC … cinnabar philosopher\\u0027s stoneWebAug 23, 2024 · The p53 Signaling PCR array includes 24 genes involved in cell cycle regulation. Results indicate that nine of these genes were significantly altered in FLT samples. ... PTTG1 (Pituitary tumor-transforming gene 1) regulates the cell cycle by inducing cyclin D3 and repressing p21 expression . cinnabar patio chair cushionsWebOct 1, 2015 · For example, PTTG1 (securin) specifically bound to p53 and interfered with DNA binding of p53, significantly reducing the transcriptional activity of p53 on p53-specific promoters . In this study, we present evidence that PTTG1, behaving as a miR-329, miR-300, miR-381 and miR-655 target gene, acts to mediate cell transformation and tumor formation. cinnabar phaseWeb[Pituitary tumor transforming gene 1 (PTTG1) is highly expressed and associated with poor prognosis in patients with hepatocellular carcinoma]. ... PTTG1 is overexpressed in nodular melanoma, and contributes to tumor progression by causing aneuploidy or by modulating p53-function; PTTG1 gene expression is mediated by Sp1 and is indirectly down ... diagnostic analytics case study