Sumo ythdf2
Web25 Aug 2016 · YT521-B homology domain family (YTHDF) proteins are the readers of m 6 A, the binding of which results in the alteration of the translation efficiency and stability of m … http://www.pacci-sh.com/usercategory/news/435082/pages/9/
Sumo ythdf2
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Web18 Mar 2024 · YTHDF2 was modified by SUMO1 with a size of Mr ∼95–100 kDa (the expected normal size of YTHDF2 is 70 kDa), which is YTHDF2 covalently conjugated with … Web16 Feb 2024 · YTH domain of YTHDF2 was a globular fold with four-stranded β-sheets (β1-β4), four α helices (α1-α4) and flanking regions on two sides. Besides, residues K416 and R527 of the above C-terminal YTH domain greatly participated in targeting RNA backbone and residues W432 and W486 within the hydrophobic pocket.
Web10 Apr 2024 · It has also been proposed that METTL14 methylates mRNAs that are targets of YTHDF2, thereby bringing in this reader [55] . Its binding may then transfer the mRNA to cellular locations where it can be degraded. ... M., Hansen, K., Puustinen, P., Gromova, I., et al. (2024) Release of Transcriptional Repression via ErbB2-Induced, SUMO-Directed ... WebThe mRNA N6-methyladenosine (m6A) modification has emerged as an essential regulator of normal and malignant hematopoiesis. Inactivation of the m6A mRNA reader YTHDF2, which recognizes m6A-modified transcripts to promote m6A-mRNA degradation, results in hematopoietic stem cell (HSC) expansion and compromises acute myeloid leukemia.
Web2 Jul 2024 · RNA-binding proteins (RBPs) are aberrantly expressed in cancer, but they remain largely unexplored as drug targets. Using RBP-focused CRISPR-Cas9 screening, Einstein et al. uncover an essential and selective role for YTHDF2 in MYC-driven breast cancer, highlighting the utility of discovering RBPs as safe and effective therapeutic targets. WebWe report 17 small-molecule ligands that compete with N6-methyladenosine (m6A) for binding to the m6A-reader domain of YTHDF2 (YT521-B homology domain family 2). We determined their binding mode at high resolution by X-ray crystallography and quantified their affinity by a fluorescence-based binding assay. 6-Cyclopropyluracil and a …
Web10 Aug 2024 · The human YTH domain family (YTHDF) proteins are RNA-binding proteins that recognize N6-methyladenosine (m6A), facilitating various biological processes via …
Web18 Feb 2024 · In this study, you propose a role for the m 6 A reader YTHDF2 in regulating the dendritic arbor size of retinal ganglion cells (RGCs). You show that retina-specific loss of Ythdf2 leads to the expansion of RGC dendritic arbors in the horizontal plane and a widening of the inner plexiform layer (IPL), with Ythdf2 conditional knockouts showing a modest … eric carle hungry caterpillar clothesWeb29 Oct 2024 · YTHDF2 directly bound to the m 6 A modification sites of LHPP and NKX3-1 to mediate the mRNA degradation. Knock-down of YTHDF2 or METTL3 significantly induced … find my scan on this computerWebYTHDF2 deficiency in TAMs suppressed tumor growth by reprogramming TAMs toward an antitumoral phenotype and increasing their antigen cross-presentation ability, which in … eric carle hungry caterpillar beddingWebYTH domain family, member 2 [Source:HGNC Symbol;Acc: 31675] Gene Synonyms HGRG8, NY-REN-2 Location Chromosome 1: 29,063,271-29,096,287 forward strand. About this transcript This transcript has 5 exons, is annotated with 7 domains and features, is associated with 10632 variant alleles and maps to 405 oligo probes. Gene find my school anne arundel countyWeb1 Jul 2024 · Major Finding: Loss of the m 6 A reader YTHDF2 compromises leukemic stem-cell activity while promoting normal HSC expansion. Mechanism: YTHDF2 decreases the half-life of m 6 A-modified mRNAs that limit LSC activity and leukemogenic potential. Impact: YTHDF2 may be therapeutic target in AML whose inhibition would also be … eric carle hungry caterpillar craftWeb13 Jun 2024 · The currently confirmed readers include YTH domain proteins (YTHDF1, YTHDF2, YTHDF3, YTHDC1 and YTHDC2) and HNRNP family proteins. 12 Among them, YTH domain family 2 (YTHDF2) is the most effective m 6 A reader, exhibiting a series of biological processes involved in cancer carcinogenesis. 14 As a main cytoplasm m 6 A … find my school based on addressWeb5 Apr 2024 · YT521-B homology domain family member 2 (YTHDF2) is an N6-methyladenosine (m6A)-binding protein that was originally found to regulate the stability of mRNA. Growing evidence has shown that YTHDF2 can participate in multifarious bioprocesses, including embryonic development, immune response, and tumor … find my schedule for school